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1-14 Motif

  • This family was first described by Rhoads and Friedberg (1997). The main feature of this family is the spacing between two bulky hydrophobic residues. Ideally, two bulky hydrophobic residues are spaced by 12 amino acid residues. Some have additional anchoring residues in the middle. It is not known whether binding affinities vary with having more bulky hydrophobic residues in the middle.
  • Two structures from this group have been solved. They are here.
  • These sequences bind to calmodulin primarily in the presence of calcium.

1-14 Subclasses

1-5-8-14 (FILVW)xxx(FAILVW)xx(FAILVW)xxxxx(FILVW)
Basic 1-8-14 (RK)(RK)(RK)(FILVW)xxxxxx(FAILVW)xxxxx(FILVW)
1-8-14 (FILVW)xxxxxx(FAILVW)xxxxx(FILVW)
1-14 (FILVW)xxxxxxxxxxxx(FILVW)
  • Residues within parentheses can substitute for each other.


Average of this Class and Links to Graphs

Sequence Alignment, Data and Homologs

Basic 1-8-14

skMLCK with Ca2+-Calmodulin
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